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diazepam decreases levels of acetaminophen rectal by raising metabolism. Minimal/Significance Unknown. Increased metabolism incr levels of hepatotoxic metabolites.
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miconazole vaginal will boost the degree or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
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diazepam will raise the amount or effect of tazemetostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Hematologic Adverse Reactions: Unusual scenarios of pancytopenia, agranulocytosis, and leukopenia have already been documented all through postmarketing use in patients addressed with APTIOM. Discontinuation of APTIOM ought to be regarded in individuals who build pancytopenia, agranulocytosis, or leukopenia.
Cessation of benzodiazepines or other CNS depressants is most popular normally. In some instances, checking at the next level of more info care for tapering CNS depressants may very well be appropriate. In Many others, slowly tapering a client off of the prescribed benzodiazepine or other CNS depressant or reducing to the lowest productive dose might be acceptable.
danazol will raise the degree or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
As diazepam rectal gel is barely supposed for adjunctive use, the prescriber should be certain that the affected person is acquiring an exceptional routine of ordinary anti-epileptic drug cure and is also, Yet, continuing to working experience these attribute episodes
diazepam will improve the degree or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Elevated flibanserin adverse outcomes might occur if coadministered with a number of weak CYP3A4 inhibitors.
Propylene glycol toxicity noted in people treated with diazepam injection at doses noticeably bigger than advised when it had been being used to take care of alcohol withdrawal signs at doses >900 mg/day Propylene glycol toxicity is connected to an anion gap metabolic acidosis, serum hyperosmolality, and amplified lactate
butalbital will lessen the level or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.